A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Rotary motion of DNA rotors on nanopores. Major row: raw online video on the Cy5 channel of each rotor. Center row: corresponding single-particle localization effects of the two finishes in the DNA rotors. The position of the present frame is marked as orange and blue dots, plus the trajectory of the 10 frames in advance of the current body is shown as reliable lines.
1996, first mesoscopic cost density waves equipment; and initial electrical measurements on an individual metallic nanocluster in between nanoelectrodes
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Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand moments in a very stable condition nanopore
2010, produced a different way (‘wedging transfer’) to govern nanostructures; initial report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores
Our exploration ranges with the biophysics of DNA to artificial cells and outside of. You should take a look underneath with the spectrum of our recent initiatives.
What distinguishes biology from chemistry is the fact these elements alongside one another make up a residing system. The key of said daily life, I think, lies from the interactions, the interplay of All those molecules. The big problem regarding the origin of lifetime continues to be unanswered. How did we at any time evolve from simple molecules to the very advanced methods we see nowadays? We do not know. I would like to operate on These types of huge, open up questions.’
Nanopores signify an elegant and flexible Instrument to measure single molecules. We research novel detection modes with solid-state nanopores as well as various ways to measure proteins with nanopores. Jobs encompass the subsequent:
‘You shouldn't just think of the inquiries of tomorrow, and also look at the thoughts of your working day immediately after tomorrow’
‘The fantastically subtle way where things in character perform by no means ceases to amaze me. If we address the puzzle of how life came into being, I hope that my amazement for the complexity of creation should have greater and with it my awe to the greatness in the Creator.’
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2001, discovery of solitary-electron transistors at area temperature determined by nanotubes; realization of 1st logic circuits with carbon nanotube products; and discovery with the molecular framework of DNA repair service enzymes with AFM
Developments in nanotechnology in the 1990s made developing electronic gadgets from single molecules a chance. Cees Dekker recounts how his group produced a space-temperature transistor according to just one carbon nanotube.
2004, discovery of latest physics in translocation of DNA through nanopores; to start with experimental examine of ions ceesdekker.net conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; initial biophysics characterization from the mechanical Attributes of double-stranded RNA; and 1st single-molecule review of DNA translocation by a restriction-modification enzyme.